| Game Name | System |
|---|
| Space Riders | MAME |
| Space Rocks (Spanish clone of Asteroids) | MAME |
| Space Seeker | MAME |
| Space Ship | MAME |
| Space Ship (Pinball) | MAME |
| Space Shuttle (L-3) | MAME |
| Space Shuttle (L-7) | MAME |
| Space Shuttle (Taito) (set 1) | MAME |
| Space Shuttle (Taito) (set 2) | MAME |
| Space Shuttle (Zaccaria) | MAME |
| Space Station (L-5) | MAME |
| Space Stranger | MAME |
| Space Stranger 2 | MAME |
| Space Tactics | MAME |
| Space Team | MAME |
| Space Thunderbird | MAME |
| Space Train | MAME |
| Space Train (Pinball) | MAME |
| Space Trek (cocktail) | MAME |
| Space Trek (upright) | MAME |
| Space Walk | MAME |
| Space War (Leijac Corporation) | MAME |
| Space War (Sanritsu) | MAME |
| Space War Part 3 | MAME |
| Space Warp? (Cosmos conversion on Galaxian hardware) | MAME |
| Space Wars | MAME |
| Space Zap | MAME |
| Spain '82 | MAME |
| Spark Man (v2.0, set 1) | MAME |
| Spark Man (v2.0, set 2) | MAME |
| Sparkz (prototype) | MAME |
| Spartacash (Maygay - Impulse) (EPOCH) (set 1) | MAME |
| Spartacash (Maygay - Impulse) (EPOCH) (set 2) | MAME |
| Spartacash (Maygay - Impulse) (EPOCH) (set 3) | MAME |
| Spartan X (Japan) | MAME |
| Spartan X (Tecfri hardware bootleg) | MAME |
| Spatter (315-5099) | MAME |
| Spatter (315-xxxx) | MAME |
| Spawn In the Demon's Hand (Rev B) | MAME |
| Speak & Help | MAME |
| Speak & Math (US, 1980 version) | MAME |
| Speak & Math (US, 1986 version) | MAME |
| Speak & Math (US, patent) | MAME |
| Speak & Read (US) | MAME |
| Speak & Rescue | MAME |
| Speak & Rescue (bootleg) | MAME |
| Speak & Spell (Japan) | MAME |
| Speak & Spell (UK, 1978 version) | MAME |
| Speak & Spell (UK, 1981 version) | MAME |
| Speak & Spell (US, 1978 version) | MAME |
| Speak & Spell (US, 1979 version) | MAME |
| Speak & Spell (US, 1980 version) | MAME |
| Speak & Spell (US, patent) | MAME |
| Speak & Spell Compact (US, 1981 version) | MAME |
| Speak & Spell Compact (US, 1982 version) | MAME |
| Speak & Write (UK) | MAME |
| Speakeasy | MAME |
| Speakeasy 4 Player | MAME |
| Special Brew (Maygay) (EPOCH) (1.1, set 1) | MAME |
| Special Brew (Maygay) (EPOCH) (1.1, set 2) | MAME |
| Special Brew (Maygay) (EPOCH) (1.3, set 3) | MAME |
| Special Brew (Maygay) (EPOCH) (1.3, set 4) | MAME |
| Special Brew (Maygay) (EPOCH) (1.4, set 10) | MAME |
| Special Brew (Maygay) (EPOCH) (1.4, set 9) | MAME |
| Special Brew (Maygay) (EPOCH) (1.5, set 5) | MAME |
| Special Brew (Maygay) (EPOCH) (1.5, set 6) | MAME |
| Special Brew (Maygay) (EPOCH) (1.6, set 7) | MAME |
| Special Brew (Maygay) (EPOCH) (1.6, set 8) | MAME |
| Special Brew (Maygay) (EPOCH) (1.8, set 11) | MAME |
| Special Brew (Maygay) (EPOCH) (1.8, set 12) | MAME |
| Special Brew (Maygay) (EPOCH) (1.9, set 13) | MAME |
| Special Brew (Maygay) (EPOCH) (1.9, set 14) | MAME |
| Special Circle Club (Barcrest) (MPU3, set 1) | MAME |
| Special Circle Club (Barcrest) (MPU3, set 2) | MAME |
| Special Circle Club (Barcrest) (MPU3, set 3) | MAME |
| Special Criminal Investigation (Japan) | MAME |
| Special Criminal Investigation (US) | MAME |
| Special Criminal Investigation (World set 1) | MAME |
| Special Criminal Investigation (World set 2) | MAME |
| Special Effects (Maygay, MV1 Video, set 1) | MAME |
| Special Effects (Maygay, MV1 Video, set 2) | MAME |
| Special Effects V2 (Maygay, MV1 Video) | MAME |
| Special Force | MAME |
| Special Forces | MAME |
| Special Forces Elite Training | MAME |
| Special Forces II | MAME |
| Special Reserve (JPM) (MPS) | MAME |
| Specialist | MAME |
| Specialist + hires graph | MAME |
| Specialist M | MAME |
| Specialist MX | MAME |
| Spectar (revision 1?) | MAME |
| Spectar (revision 3) | MAME |
| Spectra IV | MAME |
| Spectre (Bellfruit) (set 1) (Scorpion 1) | MAME |
| Spectre (Bellfruit) (set 2) (Scorpion 1) | MAME |
| Spectre (Maygay) (EPOCH) (1.3, set 3) | MAME |
| Spectre (Maygay) (EPOCH) (1.6, set 1) | MAME |
| Spectre (Maygay) (EPOCH) (1.6, set 2) | MAME |
| Spectrum | MAME |
