| Game Name | System |
|---|
| Samurai Shodown V Special / Samurai Spirits Zero Special (NGH-2720, 1st release, censored) | MAME |
| Samurai Shodown V Special / Samurai Spirits Zero Special (NGH-2720, 2nd release, less censored) | MAME |
| Samurai Shodown V Special / Samurai Spirits Zero Special (NGM-2720) | MAME |
| Samurai Shodown: Warrior's Rage / Samurai Spirits 2: Asura Zanmaden | MAME |
| Samurai Spirits Tenkaichi Kenkakuden | MAME |
| San Francisco Rush (boot rom L 1.0) | MAME |
| San Francisco Rush (boot rom L 1.06A) | MAME |
| San Francisco Rush 2049 | MAME |
| San Francisco Rush 2049: Special Edition | MAME |
| San Francisco Rush 2049: Tournament Edition | MAME |
| San Francisco Rush: The Rock (Wavenet, boot rom L 1.38, GUTS Aug 19 1997 / MAIN Aug 19 1997) | MAME |
| San Francisco Rush: The Rock (Wavenet, boot rom L 1.38, GUTS Aug 6 1997 / MAIN Aug 5 1997) | MAME |
| San Francisco Rush: The Rock (boot rom L 1.0, GUTS Oct 6 1997 / MAIN Oct 16 1997) | MAME |
| Sand Scorpion | MAME |
| Sand Scorpion (Chinese Title Screen, Revised Hardware) | MAME |
| Sand Scorpion (Earlier) | MAME |
| Sandbox PCI PC (440HX) | MAME |
| Sandbox PCI PC (440TX) | MAME |
| Sangokushi II (Asia 921005) | MAME |
| Sankokushi (Japan) | MAME |
| Sanrin San Chan (Japan, 315-xxxx) | MAME |
| Sansa Fuze 2 | MAME |
| Santa Maria (Russia) (Atronic) | MAME |
| Santana (Dutch) (Bellfruit) (Scorpion 1) | MAME |
| Sarge | MAME |
| Saru-Kani-Hamu-Zou (Japan) | MAME |
| Sasuke vs. Commander | MAME |
| Satan of Saturn (Inder S.A., bootleg) | MAME |
| Satan of Saturn (set 1) | MAME |
| Satan of Saturn (set 2) | MAME |
| Satan's Hollow (set 1) | MAME |
| Satan's Hollow (set 2) | MAME |
| Satellite (Dutch) (Bellfruit) (Scorpion 1) | MAME |
| Satellite SE (Dutch) (Bellfruit) (Scorpion 1) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (1.8, set 1) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (1.8, set 2) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (1.9, set 3) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (1.9, set 4) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (2.1, set 5) | MAME |
| Saturday Night Beaver (Global) (EPOCH) (2.1, set 6) | MAME |
| Saturday Night Beaver (Global) (Stealth?) (set 1) | MAME |
| Saturday Night Beaver (Global) (Stealth?) (set 2) | MAME |
| Saturday Night Slam Masters (USA 930713) | MAME |
| Saturday Night Slam Masters (World 930713) | MAME |
| Saturday Night Slam Masters (bootleg with PIC16c57) | MAME |
| Saturn | MAME |
| Saturn (Japan) | MAME |
| Saturn (PAL) | MAME |
| Saturn (USA) | MAME |
| Saturn 2 | MAME |
| Saulabi Spirits / Jin Saulabi Tu Hon (Korean release of Samurai Shodown II, set 1) | MAME |
| Saulabi Spirits / Jin Saulabi Tu Hon (Korean release of Samurai Shodown II, set 2) | MAME |
| Sauro | MAME |
| Sauro (Philko license) | MAME |
| Sauro (Recreativos Real S.A. license) | MAME |
| Sauro (bootleg) | MAME |
| Savage Bees | MAME |
| Savage Quest | MAME |
| Savage Reign / Fu'un Mokushiroku - Kakutou Sousei | MAME |
| Savanna (Jungler bootleg) | MAME |
| Savia 84 | MAME |
| Say No More (Barcrest) (MPU4) (set 1) | MAME |
| Say No More (Barcrest) (MPU4) (set 2) | MAME |
| Say No More (Barcrest) (MPU4) (set 3) | MAME |
| Say No More (Barcrest) (MPU4) (set 4) | MAME |
| Say No More (Barcrest) (MPU4) (set 5) | MAME |
| Scacco Matto / Space Win | MAME |
| Scandal Mahjong (Japan 890213) | MAME |
| Scandal Mahjong [BET] (Japan 890217) | MAME |
| Scared Stiff (0.3) | MAME |
| Scared Stiff (1.2) | MAME |
| Scared Stiff (1.4) | MAME |
| Scared Stiff (1.5) | MAME |
| Scared Stiff (D0.1R with sound rev.25) | MAME |
| Scatter Magic II (10001311, NSW/ACT) | MAME |
| Scatter Magic II (10102711, South Australia) | MAME |
| Schachcomputer SC-80 | MAME |
| Schachcomputer SC1 | MAME |
| Schachcomputer SC2 | MAME |
| Schmeiser Robo (Japan) | MAME |
| Scion | MAME |
| Scion (Cinematronics) | MAME |
| Scoop (Peter Simper, prototype?) (MPU3) | MAME |
| Scooter Shooter | MAME |
| Scorpion (L-1) | MAME |
| Scorpion (Moon Cresta hardware) | MAME |
| Scorpion (T-1) | MAME |
| Scorpion (set 1) | MAME |
| Scorpion (set 2) | MAME |
| Scorpion (set 3) | MAME |
| Scorpion 4 Test Rig (Bellfruit) (Scorpion ?) | MAME |
| Scorpion ZS-256 | MAME |
| Scrabble (rev. F) | MAME |
| Scrabble (rev. F) (Protocol) | MAME |
| Scramble | MAME |
| Scramble (Centromatic S.A., Spanish bootleg) | MAME |
| Scramble (Karateco, French bootleg) | MAME |
| Scramble (Model Racing, Italian bootleg) | MAME |
| Scramble (Petaco S.A., Spanish bootleg) | MAME |
| Scramble (Pinball) | MAME |
